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Publications & Presentations

These are examples of research from Tenpoint’s founders and others that are representative of findings Tenpoint will build upon as it develops its pipeline.

Reprogramming Müller glia to regenerate ganglion-like cells in adult mouse retina with developmental transcription factors
Efficient stimulation of retinal regeneration from Müller glia in adult mice using combinations of proneural bHLH transcription factors
Restoration of visual function in advanced disease after transplantation of purified human pluripotent stem cell-derived cone photoreceptors
Restoration of visual function by transplantation of optogenetically engineered photoreceptors
Clinical-grade stem cell–derived retinal pigment epithelium patch rescues retinal degeneration in rodents and pigs
Reproducibility and staging of 3D human retinal organoids across multiple pluripotent stem cell lines
Medium- to long-term survival and functional examination of human iPSC-derived retinas in rat and primate models of retinal degeneration
Characterization and Transplantation of CD73-Positive Photoreceptors Isolated from Human iPSC-Derived Retinal Organoids
Phase 1 clinical study of an embryonic stem cell–derived retinal pigment epithelium patch in age-related macular degeneration
Isolation of Human Photoreceptor Precursors via a Cell Surface Marker Panel from Stem Cell-Derived Retinal Organoids and Fetal Retinae
Human ESC–derived retinal epithelial cell sheets potentiate rescue of photoreceptor cell loss in rats with retinal degeneration
Autologous Induced Stem-Cell–Derived Retinal Cells for Macular Degeneration
Generation of Storable Retinal Organoids and Retinal Pigmented Epithelium from Adherent Human iPS Cells in Xeno-Free and Feeder-Free Conditions
Stimulation of neural regeneration in the mouse retina
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